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In sum, the data presented for isolated MMA and normal human hepatocytes demonstrate a clear effect of the BCATi to reduce labeling of products derived from valine catabolism, as well as an inhibitory effect on the reverse BCATm reaction that converts KIV to valine

2.1.3 Collapse of antioxidant defense mechanisms The antioxidant defense System in cells is critically dependent on glutathione peroxidase 4 (GPX4), a crucial metabolic enzyme that uses glutathione (GSH) to convert lipid peroxides into non-toxic alcohols, thereby minimizing harmful lipid peroxidation and safeguarding cells from ferroptosis

In this way, glutathione helps to get rid of both heavy metals and pesticides

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